Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency
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Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency
Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria. Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in the red-light region (λ(abs, max) ca. 600-680 nm, ε > 50,000 L mol(-1) cm(-1)), their low toxicit...
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Methylene blue (MB), the first lead chemical structure of phenothiazine and other derivatives, is commonly used in diagnostic procedures and as a treatment for methemoglobinemia. We have previously demonstrated that MB could function as an alternative mitochondrial electron transfer carrier, enhance cellular oxygen consumption, and provide protection in vitro and in rodent models of Parkinson's...
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Methylene blue (MB) is frequently used as an antidote in treating methemoglobinemia (1) because it facilitates the reducing activity of the NADPH-dependent methemoglobin reductase system in erythrocytes (2). However, MB absorbs strongly between 550 and 700 nm (Fig. 1 ), the same spectrophotometric region as that of the various hemoglobin derivatives: oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb),...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2013
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2013/482167